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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAPK14 All Species: 34.55
Human Site: Y258 Identified Species: 63.33
UniProt: Q16539 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16539 NP_001306.1 360 41293 Y258 S S E S A R N Y I Q S L T Q M
Chimpanzee Pan troglodytes Q95NE7 360 41475 Y258 P S H E A R N Y I Q S L T Q M
Rhesus Macaque Macaca mulatta XP_001112423 329 37756 F243 K M N F A N V F I G A N P L A
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P47811 360 41269 Y258 S S E S A R N Y I Q S L A Q M
Rat Rattus norvegicus P70618 360 41303 Y258 S S E S A R N Y I Q S L A Q M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232616 360 41440 Y258 S S E S A R N Y I Q S L S Y M
Frog Xenopus laevis P47812 361 41700 Y259 S S E A A R N Y I Q S L P Y M
Zebra Danio Brachydanio rerio Q9DGE2 361 41614 Y259 P S H E A R T Y I S S L P Q M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61443 365 42080 Y261 S S E S A R N Y I R S L P V M
Honey Bee Apis mellifera XP_395384 360 41360 Y254 L S E S A R N Y I Q S L P P L
Nematode Worm Caenorhab. elegans Q17446 377 43900 Y269 S S E E A R N Y I R N L P K M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32485 435 48840 F252 C S E N T L K F V T S L P H R
Red Bread Mold Neurospora crassa Q96TL5 358 41225 F249 A S E N T L R F V K S L P K R
Conservation
Percent
Protein Identity: 100 96.1 89.4 N.A. N.A. 99.4 98.6 N.A. N.A. 96.3 88.3 85.8 N.A. 68.4 75 62.8 N.A.
Protein Similarity: 100 97.7 90.8 N.A. N.A. 99.4 99.1 N.A. N.A. 98.6 94.7 92.2 N.A. 80.2 85 76.6 N.A.
P-Site Identity: 100 80 13.3 N.A. N.A. 93.3 93.3 N.A. N.A. 86.6 80 60 N.A. 80 73.3 66.6 N.A.
P-Site Similarity: 100 80 26.6 N.A. N.A. 93.3 93.3 N.A. N.A. 93.3 86.6 60 N.A. 86.6 80 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 42.9 50.5
Protein Similarity: N.A. N.A. N.A. N.A. 57.9 69.4
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 26.6
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 85 0 0 0 0 0 8 0 16 0 8 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 77 24 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 8 0 0 0 24 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % G
% His: 0 0 16 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 85 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 0 8 0 0 8 0 0 0 16 0 % K
% Leu: 8 0 0 0 0 16 0 0 0 0 0 93 0 8 8 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 70 % M
% Asn: 0 0 8 16 0 8 70 0 0 0 8 8 0 0 0 % N
% Pro: 16 0 0 0 0 0 0 0 0 0 0 0 62 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 54 0 0 0 39 0 % Q
% Arg: 0 0 0 0 0 77 8 0 0 16 0 0 0 0 16 % R
% Ser: 54 93 0 47 0 0 0 0 0 8 85 0 8 0 0 % S
% Thr: 0 0 0 0 16 0 8 0 0 8 0 0 16 0 0 % T
% Val: 0 0 0 0 0 0 8 0 16 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 77 0 0 0 0 0 16 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _